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Population Pharmacokinetics of Fosdagrocorat (PF‐04171327), a Dissociated Glucocorticoid Receptor Agonist, in Patients With Rheumatoid Arthritis

Dissociated agonists of the glucocorticoid receptor (DAGRs) show similar antiinflammatory effects but improved tolerability compared with standard glucocorticoid receptor (GR) agonists. The prodrug fosdagrocorat (PF‐04171327), with active DAGR metabolite PF‐00251802 (Metabolite‐1), is postulated to...

詳細記述

保存先:
書誌詳細
出版年:Clin Transl Sci
主要な著者: Weatherley, Barry, McFadyen, Lynn, Tammara, Brinda
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5759734/
https://ncbi.nlm.nih.gov/pubmed/29106053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12515
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