Molecular motion regulates the activity of the Mitochondrial Serine Protease HtrA2

HtrA2 (high-temperature requirement 2) is a human mitochondrial protease that has a role in apoptosis and Parkinson’s disease. The structure of HtrA2 with an intact catalytic triad was determined, revealing a conformational change in the active site loops, involving mainly the regulatory LD loop, wh...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Death Dis
Hauptverfasser: Merski, Matthew, Moreira, Cátia, Abreu, Rui MV, Ramos, Maria João, Fernandes, Pedro A, Martins, L Miguel, Pereira, Pedro José Barbosa, Macedo-Ribeiro, Sandra
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5759095/
https://ncbi.nlm.nih.gov/pubmed/29022916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.487
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