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Molecular motion regulates the activity of the Mitochondrial Serine Protease HtrA2
HtrA2 (high-temperature requirement 2) is a human mitochondrial protease that has a role in apoptosis and Parkinson’s disease. The structure of HtrA2 with an intact catalytic triad was determined, revealing a conformational change in the active site loops, involving mainly the regulatory LD loop, wh...
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| Publicat a: | Cell Death Dis |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5759095/ https://ncbi.nlm.nih.gov/pubmed/29022916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.487 |
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