Mechanism of formation of a toroid around DNA by the mismatch sensor protein

The DNA mismatch repair (MMR) pathway removes errors that appear during genome replication. MutS is the primary mismatch sensor and forms an asymmetric dimer that encircles DNA to bend it to scan for mismatches. The mechanism utilized to load DNA into the central tunnel was unknown and the origin of...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Nirwal, Shivlee, Kulkarni, Dhananjaya S, Sharma, Amit, Rao, Desirazu N, Nair, Deepak T
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5758902/
https://ncbi.nlm.nih.gov/pubmed/29182773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1149
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