Mechanism of formation of a toroid around DNA by the mismatch sensor protein

The DNA mismatch repair (MMR) pathway removes errors that appear during genome replication. MutS is the primary mismatch sensor and forms an asymmetric dimer that encircles DNA to bend it to scan for mismatches. The mechanism utilized to load DNA into the central tunnel was unknown and the origin of...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nucleic Acids Res
Egile Nagusiak: Nirwal, Shivlee, Kulkarni, Dhananjaya S, Sharma, Amit, Rao, Desirazu N, Nair, Deepak T
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2018
Gaiak:
Genome Integrity, Repair and Replication
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5758902/
https://ncbi.nlm.nih.gov/pubmed/29182773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1149
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