Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins

Human Pumilio proteins, PUM1 and PUM2, are sequence specific RNA-binding proteins that regulate protein expression. We used RNA-seq, rigorous statistical testing and an experimentally derived fold change cut-off to identify nearly 1000 target RNAs—including mRNAs and non-coding RNAs—that are functio...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Bohn, Jennifer A, Van Etten, Jamie L, Schagat, Trista L, Bowman, Brittany M, McEachin, Richard C, Freddolino, Peter L, Goldstrohm, Aaron C
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
RNA and RNA-protein complexes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5758885/
https://ncbi.nlm.nih.gov/pubmed/29165587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1120
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