Blockade of soluble epoxide hydrolase attenuates post-ischemic neuronal hyperexcitation and confers resilience against stroke with TrkB activation

Inhibition and deletion of soluble epoxide hydrolase (sEH) has been suggested to ameliorate infarction in experimental ischemic stroke possibly via vasoactive epoxyeicosatrienoic acids. However, it is unknown whether the neuroprotective mechanisms involve alteration of post-ischemic neuronal transmi...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Chang, Li-Hsin, Lin, Hui-Ching, Huang, Shiang-Suo, Chen, I-Chih, Chu, Kai-Wen, Chih, Chun-Lien, Liang, Yao-Wen, Lee, Yi-Chung, Chen, You-Yin, Lee, Yi-Hsuan, Lee, I-Hui
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5758800/
https://ncbi.nlm.nih.gov/pubmed/29311641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18558-6
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