SUSTAINED BLOCKADE OF NEUROTROPHIN RECEPTORS TrkA, TrkB AND TrkC REDUCES NON-MALIGNANT SKELETAL PAIN BUT NOT THE MAINTENANCE OF SENSORY AND SYMPATHETIC NERVE FIBERS

Current therapies for treating skeletal pain have significant limitations as available drugs (nonsteroidal anti-inflammatory drugs and opiates) have significant unwanted side effects. Targeting nerve growth factor or it's cognate receptor Tropomysin receptor kinase A (TrkA) has recently become...

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Main Authors: Ghilardi, Joseph R., Freeman, Katie T., Jimenez-Andrade, Juan M., Mantyh, William G., Bloom, Aaron P., Bouhana, Karyn S., Trollinger, David, Winkler, James, Lee, Patrice, Andrews, Steven W., Kuskowski, Michael A., Mantyh, Patrick W.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020250/
https://ncbi.nlm.nih.gov/pubmed/20854944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2010.09.019
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