Distinct SoxB1 networks are required for naïve and primed pluripotency

Deletion of Sox2 from mouse embryonic stem cells (ESCs) causes trophectodermal differentiation. While this can be prevented by enforced expression of the related SOXB1 proteins, SOX1 or SOX3, the roles of SOXB1 proteins in epiblast stem cell (EpiSC) pluripotency are unknown. Here, we show that Sox2...

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Veröffentlicht in:eLife
Hauptverfasser: Corsinotti, Andrea, Wong, Frederick CK, Tatar, Tülin, Szczerbinska, Iwona, Halbritter, Florian, Colby, Douglas, Gogolok, Sabine, Pantier, Raphaël, Liggat, Kirsten, Mirfazeli, Elham S, Hall-Ponsele, Elisa, Mullin, Nicholas P, Wilson, Valerie, Chambers, Ian
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2017
Schlagworte:
Stem Cells and Regenerative Medicine
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5758114/
https://ncbi.nlm.nih.gov/pubmed/29256862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27746
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