Distinct SoxB1 networks are required for naïve and primed pluripotency

Deletion of Sox2 from mouse embryonic stem cells (ESCs) causes trophectodermal differentiation. While this can be prevented by enforced expression of the related SOXB1 proteins, SOX1 or SOX3, the roles of SOXB1 proteins in epiblast stem cell (EpiSC) pluripotency are unknown. Here, we show that Sox2...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Corsinotti, Andrea, Wong, Frederick CK, Tatar, Tülin, Szczerbinska, Iwona, Halbritter, Florian, Colby, Douglas, Gogolok, Sabine, Pantier, Raphaël, Liggat, Kirsten, Mirfazeli, Elham S, Hall-Ponsele, Elisa, Mullin, Nicholas P, Wilson, Valerie, Chambers, Ian
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2017
Fag:
Stem Cells and Regenerative Medicine
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5758114/
https://ncbi.nlm.nih.gov/pubmed/29256862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27746
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