Inhibition of GABA transporters fails to afford significant protection following focal cerebral ischemia

Brain ischemia triggers excitotoxicity and cell death, yet no neuroprotective drugs have made it to the clinic. While enhancing GABAergic signaling to counterbalance excitotoxicity has shown promise in animal models, clinical studies have failed. Blockade of GABA transporters (GATs) offers an indire...

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Dades bibliogràfiques
Publicat a:J Cereb Blood Flow Metab
Autors principals: Lie, Maria EK, Gowing, Emma K, Clausen, Rasmus P, Wellendorph, Petrine, Clarkson, Andrew N
Format: Artigo
Idioma:Inglês
Publicat: SAGE Publications 2017
Matèries:
Negative Results
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5757447/
https://ncbi.nlm.nih.gov/pubmed/29148909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X17743669
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