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Inhibition of GABA transporters fails to afford significant protection following focal cerebral ischemia
Brain ischemia triggers excitotoxicity and cell death, yet no neuroprotective drugs have made it to the clinic. While enhancing GABAergic signaling to counterbalance excitotoxicity has shown promise in animal models, clinical studies have failed. Blockade of GABA transporters (GATs) offers an indire...
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| Veröffentlicht in: | J Cereb Blood Flow Metab |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
SAGE Publications
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5757447/ https://ncbi.nlm.nih.gov/pubmed/29148909 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X17743669 |
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