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Shigella hijacks the glomulin–cIAPs–inflammasome axis to promote inflammation
Shigella deploys a unique mechanism to manipulate macrophage pyroptosis by delivering the IpaH7.8 E3 ubiquitin ligase via its type III secretion system. IpaH7.8 ubiquitinates glomulin (GLMN) and elicits its degradation, thereby inducing inflammasome activation and pyroptotic cell death of macrophage...
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| Pubblicato in: | EMBO Rep |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5757219/ https://ncbi.nlm.nih.gov/pubmed/29191979 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201643841 |
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