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Shigella hijacks the glomulin–cIAPs–inflammasome axis to promote inflammation

Shigella deploys a unique mechanism to manipulate macrophage pyroptosis by delivering the IpaH7.8 E3 ubiquitin ligase via its type III secretion system. IpaH7.8 ubiquitinates glomulin (GLMN) and elicits its degradation, thereby inducing inflammasome activation and pyroptotic cell death of macrophage...

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Bibliografiske detaljer
Udgivet i:EMBO Rep
Main Authors: Suzuki, Shiho, Suzuki, Toshihiko, Mimuro, Hitomi, Mizushima, Tsunehiro, Sasakawa, Chihiro
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5757219/
https://ncbi.nlm.nih.gov/pubmed/29191979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201643841
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