Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induces Post-Translational Modifications of AKAP121, DRP1 and OPA1 That Promote Mitochondrial Fission

RATIONALE: Cardiac lipotoxicity, characterized by increased uptake, oxidation and accumulation of lipid intermediates, contributes to cardiac dysfunction in obesity and diabetes. However, mechanisms linking lipid overload and mitochondrial dysfunction are incompletely understood. OBJECTIVE: To eluci...

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Udgivet i:Circ Res
Main Authors: Tsushima, Kensuke, Bugger, Heiko, Wende, Adam R., Soto, Jamie, Jenson, Gregory A., Tor, Austin R., McGlauflin, Rose, Kenny, Helena C., Zhang, Yuan, Souvenir, Rhonda, Hu, Xiao X., Sloan, Crystal L., Pereira, Renata O., Lira, Vitor A, Spitzer, Kenneth W., Sharp, Terry L., Shoghi, Kooresh I., Sparagna, Genevieve C., Rog-Zielinska, Eva A., Kohl, Peter, Khalimonchuk, Oleh, Schaffer, Jean E., Abel, E. Dale
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5756120/
https://ncbi.nlm.nih.gov/pubmed/29092894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.311307
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