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The sorafenib anti-relapse effect after alloHSCT is associated with heightened alloreactivity and accumulation of CD8+PD-1+ (CD279+) lymphocytes in marrow

We studied three FLT3 ITD acute myeloid leukemia (AML) patients who relapsed after allogeneic haematopoietic stem cell transplantation (alloHSCT) and received multikinase inhibitor (MKI) sorafenib as part of salvage therapy. MKI was given to block the effect of FLT3 ITD mutation which powers prolife...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:PLoS One
Κύριοι συγγραφείς: Lange, Andrzej, Jaskula, Emilia, Lange, Janusz, Dworacki, Grzegorz, Nowak, Dorota, Simiczyjew, Aleksandra, Mordak-Domagala, Monika, Sedzimirska, Mariola
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2018
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5755786/
https://ncbi.nlm.nih.gov/pubmed/29304116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0190525
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