The sorafenib anti-relapse effect after alloHSCT is associated with heightened alloreactivity and accumulation of CD8+PD-1+ (CD279+) lymphocytes in marrow

We studied three FLT3 ITD acute myeloid leukemia (AML) patients who relapsed after allogeneic haematopoietic stem cell transplantation (alloHSCT) and received multikinase inhibitor (MKI) sorafenib as part of salvage therapy. MKI was given to block the effect of FLT3 ITD mutation which powers prolife...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lange, Andrzej, Jaskula, Emilia, Lange, Janusz, Dworacki, Grzegorz, Nowak, Dorota, Simiczyjew, Aleksandra, Mordak-Domagala, Monika, Sedzimirska, Mariola
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5755786/
https://ncbi.nlm.nih.gov/pubmed/29304116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0190525
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