The immunophilin FKBP12 inhibits hepcidin expression by binding the BMP type I receptor ALK2 in hepatocytes

The expression of the key regulator of iron homeostasis hepcidin is activated by the BMP-SMAD pathway in response to iron and inflammation and among drugs, by rapamycin, which inhibits mTOR in complex with the immunophilin FKBP12. FKBP12 interacts with BMP type I receptors to avoid uncontrolled sign...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Blood
Hauptverfasser: Colucci, Silvia, Pagani, Alessia, Pettinato, Mariateresa, Artuso, Irene, Nai, Antonella, Camaschella, Clara, Silvestri, Laura
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2017
Schlagworte:
Red Cells, Iron, and Erythropoiesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5755682/
https://ncbi.nlm.nih.gov/pubmed/28864813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-04-780692
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