Pharmacokinetics comparison of two pegylated interferon alfa formulations in healthy volunteers

BACKGROUND: Several countries have used pegylation technology to improve the pharmacokinetic properties of essential drugs. Recently, a novel interferon alfa-2b protein conjugated to four-branched 12 kDa polyethylene glycol molecules was developed jointly between Cuba and Brazil. The aim of this stu...

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Enregistré dans:
Détails bibliographiques
Publié dans:BMC Pharmacol Toxicol
Auteurs principaux: Costa, Marisa Boff, Picon, Paulo Dornelles, Sander, Guilherme Becker, Cuni, Hugo Nodarse, Silva, Carmen Valenzuela, Meireles, Rolando Páez, Góes, Ana Carolina Magalhães Andrade, Batoreu, Nadia Maria, Maia, Maria de Lourdes de Sousa, Albuquerque, Elizabeth Maciel, Matos, Denise Cristina de Souza, Saura, Pedro Lopez
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5755306/
https://ncbi.nlm.nih.gov/pubmed/29301580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40360-017-0192-z
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