Phase Ib/II Study of Pembrolizumab and Pegylated-Interferon Alfa-2b in Advanced Melanoma

PURPOSE: Objective responses are reported in 34% to 37% of patients with programmed death-1 (PD-1)–naïve advanced melanoma treated with PD-1 inhibitors. Pre-existing CD8+ T-cell infiltrate and interferon (IFN) gene signature correlate with response to PD-1 blockade. Here, we report a phase Ib/II stu...

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Detalhes bibliográficos
Publicado no:J Clin Oncol
Main Authors: Davar, Diwakar, Wang, Hong, Chauvin, Joe-Marc, Pagliano, Ornella, Fourcade, Julien J., Ka, Mignane, Menna, Carmine, Rose, Amy, Sander, Cindy, Borhani, Amir A., Karunamurthy, Arivarasan, Tarhini, Ahmad A., Tawbi, Hussein A., Zhao, Qing, Moreno, Blanca H., Ebbinghaus, Scott, Ibrahim, Nageatte, Kirkwood, John M., Zarour, Hassane M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2018
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6286160/
https://ncbi.nlm.nih.gov/pubmed/30359157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.18.00632
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