Modeling Amyloid-β42 Toxicity and Neurodegeneration in Adult Zebrafish Brain

Alzheimer's disease (AD) is a debilitating neurodegenerative disease in which accumulation of toxic amyloid-β42 (Aβ42) peptides leads to synaptic degeneration, inflammation, neuronal death, and learning deficits. Humans cannot regenerate lost neurons in the case of AD in part due to impaired pr...

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Bibliografiske detaljer
Udgivet i:J Vis Exp
Main Authors: Bhattarai, Prabesh, Thomas, Alvin Kuriakose, Cosacak, Mehmet Ilyas, Papadimitriou, Christos, Mashkaryan, Violeta, Zhang, Yixin, Kizil, Caghan
Format: Artigo
Sprog:Inglês
Udgivet: MyJove Corporation 2017
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5755241/
https://ncbi.nlm.nih.gov/pubmed/29155703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/56014
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