Human TAU(P301L) overexpression results in TAU hyperphosphorylation without neurofibrillary tangles in adult zebrafish brain

Microtubule-associated TAU protein is a pathological hallmark in Alzheimer’s disease (AD), where hyperphosphorylation of TAU generates neurofibrillary tangles. To investigate the effects of TAU in a regenerative adult vertebrate brain system, we generated a cre/lox-based transgenic model of zebrafis...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Cosacak, Mehmet I., Bhattarai, Prabesh, Bocova, Ledio, Dzewas, Tim, Mashkaryan, Violeta, Papadimitriou, Christos, Brandt, Kerstin, Hollak, Heike, Antos, Christopher L., Kizil, Caghan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636889/
https://ncbi.nlm.nih.gov/pubmed/29021554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13311-5
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