Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome

Phosphorylation is a major regulator of protein interactions; however, the mechanisms by which regulation occurs are not well understood. Here we identify a salt-bridge competition or “theft” mechanism that enables a phospho-triggered swap of protein partners by Raf Kinase Inhibitory Protein (RKIP)....

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Skinner, John J., Wang, Sheng, Lee, Jiyoung, Ong, Colin, Sommese, Ruth, Sivaramakrishnan, Sivaraj, Koelmel, Wolfgang, Hirschbeck, Maria, Schindelin, Hermann, Kisker, Caroline, Lorenz, Kristina, Sosnick, Tobin R., Rosner, Marsha Rich
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5754776/
https://ncbi.nlm.nih.gov/pubmed/29208709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711543114
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