Predictive role of NUDT15 variants on thiopurine-induced myelotoxicity in Asian inflammatory bowel disease patients

BACKGROUND: Genetic variants of TPMT and NUDT15 have been reported to predict the inter-patient variability in response and toxicity profiles of patients receiving thiopurine therapy. However, the clinical utility of TPMT genotyping in guiding thiopurine doses has been questionable, in part due to u...

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Veröffentlicht in:Pharmacogenomics
Hauptverfasser: Sutiman, Natalia, Chen, Sylvia, Ling, Khoon Lin, Chuah, Sai Wei, Leong, Wai Fook, Nadiger, Vinayak, Tjai, Madeline, Choon Kong, Chris San, Schwender, Brian John, Chan, Webber, Shim, Hang Hock, Lim, Wee Chian, Khor, Chiea Chuen, Cheung, Yin Bun, Chowbay, Balram
Format: Artigo
Sprache:Inglês
Veröffentlicht: Future Medicine Ltd 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5753614/
https://ncbi.nlm.nih.gov/pubmed/29210335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs-2017-0147
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