Predictive role of NUDT15 variants on thiopurine-induced myelotoxicity in Asian inflammatory bowel disease patients

BACKGROUND: Genetic variants of TPMT and NUDT15 have been reported to predict the inter-patient variability in response and toxicity profiles of patients receiving thiopurine therapy. However, the clinical utility of TPMT genotyping in guiding thiopurine doses has been questionable, in part due to u...

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Enregistré dans:
Détails bibliographiques
Publié dans:Pharmacogenomics
Auteurs principaux: Sutiman, Natalia, Chen, Sylvia, Ling, Khoon Lin, Chuah, Sai Wei, Leong, Wai Fook, Nadiger, Vinayak, Tjai, Madeline, Choon Kong, Chris San, Schwender, Brian John, Chan, Webber, Shim, Hang Hock, Lim, Wee Chian, Khor, Chiea Chuen, Cheung, Yin Bun, Chowbay, Balram
Format: Artigo
Langue:Inglês
Publié: Future Medicine Ltd 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5753614/
https://ncbi.nlm.nih.gov/pubmed/29210335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs-2017-0147
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