Predictive role of NUDT15 variants on thiopurine-induced myelotoxicity in Asian inflammatory bowel disease patients

BACKGROUND: Genetic variants of TPMT and NUDT15 have been reported to predict the inter-patient variability in response and toxicity profiles of patients receiving thiopurine therapy. However, the clinical utility of TPMT genotyping in guiding thiopurine doses has been questionable, in part due to u...

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Gepubliceerd in:Pharmacogenomics
Hoofdauteurs: Sutiman, Natalia, Chen, Sylvia, Ling, Khoon Lin, Chuah, Sai Wei, Leong, Wai Fook, Nadiger, Vinayak, Tjai, Madeline, Choon Kong, Chris San, Schwender, Brian John, Chan, Webber, Shim, Hang Hock, Lim, Wee Chian, Khor, Chiea Chuen, Cheung, Yin Bun, Chowbay, Balram
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Future Medicine Ltd 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5753614/
https://ncbi.nlm.nih.gov/pubmed/29210335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs-2017-0147
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