LCZ696 (Sacubitril/valsartan) ameliorates oxidative stress, inflammation, fibrosis and improves renal function beyond angiotensin receptor blockade in CKD

Progressive deterioration of kidney function in chronic kidney disease (CKD) is mediated by hypertension, oxidative stress, inflammation, and fibrosis. Renin-angiotensin blockade is commonly used to retard CKD progression. In addition, vasoactive peptides have been shown to reduce blood pressure and...

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Dettagli Bibliografici
Pubblicato in:Am J Transl Res
Autori principali: Jing, Wanghui, Vaziri, Nosratola D, Nunes, Ane, Suematsu, Yasunori, Farzaneh, Ted, Khazaeli, Mahyar, Moradi, Hamid
Natura: Artigo
Lingua:Inglês
Pubblicazione: e-Century Publishing Corporation 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752897/
https://ncbi.nlm.nih.gov/pubmed/29312499
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