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Portending death in germinal centers — when B cells know their time is up

B cells undergo stringent selection in germinal centers (GCs) for expression of high-affinity antibodies, however, mechanisms of negative selection of low-affinity B cell clones remain elusive. A new study by Michel Nussenzweig's group published in Science leverages a new reporter system that m...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Wang, Lili, Müschen, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752846/
https://ncbi.nlm.nih.gov/pubmed/29192678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.151
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