Mouse embryonic stem cells have increased capacity for replication fork restart driven by the specific Filia-Floped protein complex

Pluripotent stem cells (PSCs) harbor constitutive DNA replication stress during their rapid proliferation and the consequent genome instability hampers their applications in regenerative medicine. It is therefore important to understand the regulatory mechanisms of replication stress response in PSC...

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Publicado en:Cell Res
Autores principales: Zhao, Bo, Zhang, Weidao, Cun, Yixian, Li, Jingzheng, Liu, Yan, Gao, Jing, Zhu, Hongwen, Zhou, Hu, Zhang, Rugang, Zheng, Ping
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2018
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752841/
https://ncbi.nlm.nih.gov/pubmed/29125140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.139
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