Angiotensin-converting enzyme defines matrikine-regulated inflammation and fibrosis

The neutrophil chemoattractant proline-glycine-proline (PGP) is generated from collagen by matrix metalloproteinase-8/9 (MMP-8/9) and prolyl endopeptidase (PE), and it is concomitantly degraded by extracellular leukotriene A(4) hydrolase (LTA(4)H) to limit neutrophilia. Components of cigarette smoke...

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Bibliografski detalji
Izdano u:JCI Insight
Glavni autori: O’Reilly, Philip J., Ding, Qiang, Akthar, Samia, Cai, Guoqiang, Genschmer, Kristopher R., Patel, Dhiren F., Jackson, Patricia L., Viera, Liliana, Roda, Mojtaba, Locy, Morgan L., Bernstein, Ellen A., Lloyd, Clare M., Bernstein, Kenneth E., Snelgrove, Robert J., Blalock, J. Edwin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2017
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752376/
https://ncbi.nlm.nih.gov/pubmed/29202450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.91923
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