Angiotensin-converting enzyme defines matrikine-regulated inflammation and fibrosis

The neutrophil chemoattractant proline-glycine-proline (PGP) is generated from collagen by matrix metalloproteinase-8/9 (MMP-8/9) and prolyl endopeptidase (PE), and it is concomitantly degraded by extracellular leukotriene A(4) hydrolase (LTA(4)H) to limit neutrophilia. Components of cigarette smoke...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: O’Reilly, Philip J., Ding, Qiang, Akthar, Samia, Cai, Guoqiang, Genschmer, Kristopher R., Patel, Dhiren F., Jackson, Patricia L., Viera, Liliana, Roda, Mojtaba, Locy, Morgan L., Bernstein, Ellen A., Lloyd, Clare M., Bernstein, Kenneth E., Snelgrove, Robert J., Blalock, J. Edwin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752376/
https://ncbi.nlm.nih.gov/pubmed/29202450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.91923
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