Addition of carbonic anhydrase 9 inhibitor SLC-0111 to temozolomide treatment delays glioblastoma growth in vivo

Tumor microenvironments can promote stem cell maintenance, tumor growth, and therapeutic resistance, findings linked by the tumor-initiating cell hypothesis. Standard of care for glioblastoma (GBM) includes temozolomide chemotherapy, which is not curative, due, in part, to residual therapy-resistant...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Boyd, Nathaniel H., Walker, Kiera, Fried, Joshua, Hackney, James R., McDonald, Paul C., Benavides, Gloria A., Spina, Raffaella, Audia, Alessandra, Scott, Sarah E., Landis, Catherine J., Tran, Anh Nhat, Bevensee, Mark O., Griguer, Corinne, Nozell, Susan, Gillespie, G. Yancey, Nabors, Burt, Bhat, Krishna P., Bar, Eli E., Darley-Usmar, Victor, Xu, Bo, Gordon, Emily, Cooper, Sara J., Dedhar, Shoukat, Hjelmeland, Anita B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752277/
https://ncbi.nlm.nih.gov/pubmed/29263302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92928
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