Addition of carbonic anhydrase 9 inhibitor SLC-0111 to temozolomide treatment delays glioblastoma growth in vivo

Tumor microenvironments can promote stem cell maintenance, tumor growth, and therapeutic resistance, findings linked by the tumor-initiating cell hypothesis. Standard of care for glioblastoma (GBM) includes temozolomide chemotherapy, which is not curative, due, in part, to residual therapy-resistant...

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Udgivet i:JCI Insight
Main Authors: Boyd, Nathaniel H., Walker, Kiera, Fried, Joshua, Hackney, James R., McDonald, Paul C., Benavides, Gloria A., Spina, Raffaella, Audia, Alessandra, Scott, Sarah E., Landis, Catherine J., Tran, Anh Nhat, Bevensee, Mark O., Griguer, Corinne, Nozell, Susan, Gillespie, G. Yancey, Nabors, Burt, Bhat, Krishna P., Bar, Eli E., Darley-Usmar, Victor, Xu, Bo, Gordon, Emily, Cooper, Sara J., Dedhar, Shoukat, Hjelmeland, Anita B.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752277/
https://ncbi.nlm.nih.gov/pubmed/29263302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92928
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