PI3Kα inactivation in leptin receptor cells increases leptin sensitivity but disrupts growth and reproduction

The role of PI3K in leptin physiology has been difficult to determine due to its actions downstream of several metabolic cues, including insulin. Here, we used a series of mouse models to dissociate the roles of specific PI3K catalytic subunits and of insulin receptor (InsR) downstream of leptin sig...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Garcia-Galiano, David, Borges, Beatriz C., Donato, Jose, Allen, Susan J., Bellefontaine, Nicole, Wang, Mengjie, Zhao, Jean J., Kozloff, Kenneth M., Hill, Jennifer W., Elias, Carol F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752267/
https://ncbi.nlm.nih.gov/pubmed/29212950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96728
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