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PI3Kα inactivation in leptin receptor cells increases leptin sensitivity but disrupts growth and reproduction
The role of PI3K in leptin physiology has been difficult to determine due to its actions downstream of several metabolic cues, including insulin. Here, we used a series of mouse models to dissociate the roles of specific PI3K catalytic subunits and of insulin receptor (InsR) downstream of leptin sig...
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| Publicado no: | JCI Insight |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5752267/ https://ncbi.nlm.nih.gov/pubmed/29212950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96728 |
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