Loss of miR-107, miR-181c and miR-29a-3p Promote Activation of Notch2 Signaling in Pediatric High-Grade Gliomas (pHGGs)

The mechanisms by which microRNAs control pediatric high-grade gliomas (pHGGs) have yet to be fully elucidated. Our studies of patient-derived pHGG tissues and of the pHGG cell line KNS42 revealed down-regulation in these tumors of three microRNAs, specifically miR-107, miR-181c, and miR-29a-3p. Thi...

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Udgivet i:Int J Mol Sci
Main Authors: Catanzaro, Giuseppina, Sabato, Claudia, Russo, Michele, Rosa, Alessandro, Abballe, Luana, Besharat, Zein Mersini, Po, Agnese, Miele, Evelina, Bellavia, Diana, Chiacchiarini, Martina, Gessi, Marco, Peruzzi, Giovanna, Napolitano, Maddalena, Antonelli, Manila, Mastronuzzi, Angela, Giangaspero, Felice, Locatelli, Franco, Screpanti, Isabella, Vacca, Alessandra, Ferretti, Elisabetta
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5751342/
https://ncbi.nlm.nih.gov/pubmed/29258209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18122742
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