Novel Sarcopenia-related Alterations in Sarcomeric Protein Post-translational Modifications (PTMs) in Skeletal Muscles Identified by Top-down Proteomics

Sarcopenia, the age-related loss of skeletal muscle mass and strength, is a significant cause of morbidity in the elderly and is a major burden on health care systems. Unfortunately, the underlying molecular mechanisms in sarcopenia remain poorly understood. Herein, we utilized top-down proteomics t...

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Detalles Bibliográficos
Publicado en:Mol Cell Proteomics
Main Authors: Wei, Liming, Gregorich, Zachery R., Lin, Ziqing, Cai, Wenxuan, Jin, Yutong, McKiernan, Susan H., McIlwain, Sean, Aiken, Judd M., Moss, Richard L., Diffee, Gary M., Ge, Ying
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5750843/
https://ncbi.nlm.nih.gov/pubmed/29046390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA117.000124
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