Stability of the Influenza Virus Hemagglutinin Protein Correlates with Evolutionary Dynamics

Protein thermodynamics are an integral determinant of viral fitness and one of the major drivers of protein evolution. Mutations in the influenza A virus (IAV) hemagglutinin (HA) protein can eliminate neutralizing antibody binding to mediate escape from preexisting antiviral immunity. Prior research...

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Detalhes bibliográficos
Publicado no:mSphere
Main Authors: Klein, Eili Y., Blumenkrantz, Deena, Serohijos, Adrian, Shakhnovich, Eugene, Choi, Jeong-Mo, Rodrigues, João V., Smith, Brendan D., Lane, Andrew P., Feldman, Andrew, Pekosz, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5750392/
https://ncbi.nlm.nih.gov/pubmed/29299534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphereDirect.00554-17
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