Stability of the Influenza Virus Hemagglutinin Protein Correlates with Evolutionary Dynamics

Protein thermodynamics are an integral determinant of viral fitness and one of the major drivers of protein evolution. Mutations in the influenza A virus (IAV) hemagglutinin (HA) protein can eliminate neutralizing antibody binding to mediate escape from preexisting antiviral immunity. Prior research...

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Veröffentlicht in:mSphere
Hauptverfasser: Klein, Eili Y., Blumenkrantz, Deena, Serohijos, Adrian, Shakhnovich, Eugene, Choi, Jeong-Mo, Rodrigues, João V., Smith, Brendan D., Lane, Andrew P., Feldman, Andrew, Pekosz, Andrew
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5750392/
https://ncbi.nlm.nih.gov/pubmed/29299534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphereDirect.00554-17
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