Stability of the Influenza Virus Hemagglutinin Protein Correlates with Evolutionary Dynamics

Protein thermodynamics are an integral determinant of viral fitness and one of the major drivers of protein evolution. Mutations in the influenza A virus (IAV) hemagglutinin (HA) protein can eliminate neutralizing antibody binding to mediate escape from preexisting antiviral immunity. Prior research...

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Vydáno v:mSphere
Hlavní autoři: Klein, Eili Y., Blumenkrantz, Deena, Serohijos, Adrian, Shakhnovich, Eugene, Choi, Jeong-Mo, Rodrigues, João V., Smith, Brendan D., Lane, Andrew P., Feldman, Andrew, Pekosz, Andrew
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2018
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5750392/
https://ncbi.nlm.nih.gov/pubmed/29299534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphereDirect.00554-17
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