A Single Amino Acid Change in the Marburg Virus Glycoprotein Arises during Serial Cell Culture Passages and Attenuates the Virus in a Macaque Model of Disease

Marburg virus (MARV) causes disease with high case fatality rates, and there are no approved vaccines or therapies. Licensing of MARV countermeasures will likely require approval via the FDA’s Animal Efficacy Rule, which requires well-characterized animal models that recapitulate human disease. This...

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Detalhes bibliográficos
Publicado no:mSphere
Main Authors: Alfson, Kendra J., Avena, Laura E., Delgado, Jenny, Beadles, Michael W., Patterson, Jean L., Carrion, Ricardo, Griffiths, Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5750385/
https://ncbi.nlm.nih.gov/pubmed/29299527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00401-17
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