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A Single Amino Acid Change in the Marburg Virus Glycoprotein Arises during Serial Cell Culture Passages and Attenuates the Virus in a Macaque Model of Disease

Marburg virus (MARV) causes disease with high case fatality rates, and there are no approved vaccines or therapies. Licensing of MARV countermeasures will likely require approval via the FDA’s Animal Efficacy Rule, which requires well-characterized animal models that recapitulate human disease. This...

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Foilsithe in:mSphere
Main Authors: Alfson, Kendra J., Avena, Laura E., Delgado, Jenny, Beadles, Michael W., Patterson, Jean L., Carrion, Ricardo, Griffiths, Anthony
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2018
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5750385/
https://ncbi.nlm.nih.gov/pubmed/29299527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00401-17
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