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Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis
Multiple sclerosis (MS) is a T cell-mediated autoimmune disease of the central nervous system. Foxp3(+) regulatory T (Treg) cells are reduced in frequency and dysfunctional in patients with MS, but the underlying mechanisms of this deficiency are unclear. Here, we show that induction of human IFN-γ(...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5750223/ https://ncbi.nlm.nih.gov/pubmed/29295981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02406-2 |
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