Perturbation-response genes reveal signaling footprints in cancer gene expression

Aberrant cell signaling can cause cancer and other diseases and is a focal point of drug research. A common approach is to infer signaling activity of pathways from gene expression. However, mapping gene expression to pathway components disregards the effect of post-translational modifications, and...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Schubert, Michael, Klinger, Bertram, Klünemann, Martina, Sieber, Anja, Uhlitz, Florian, Sauer, Sascha, Garnett, Mathew J., Blüthgen, Nils, Saez-Rodriguez, Julio
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5750219/
https://ncbi.nlm.nih.gov/pubmed/29295995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02391-6
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