Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein

Impaired hepatic glucose uptake (HGU) causes postprandial hyperglycemia in type 2 diabetes. Here, we show that diminished hepatic Sirt2 activity impairs HGU in obese diabetic mice. Hepatic Sirt2 overexpression increases HGU in high-fat diet (HFD)-fed obese diabetic mice and mitigates their impaired...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Watanabe, Hitoshi, Inaba, Yuka, Kimura, Kumi, Matsumoto, Michihiro, Kaneko, Shuichi, Kasuga, Masato, Inoue, Hiroshi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5750207/
https://ncbi.nlm.nih.gov/pubmed/29296001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02537-6
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