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V1b receptor antagonist SSR149415 and naltrexone synergistically decrease excessive alcohol drinking in male and female mice

BACKGROUND: A recent clinical trial found that pharmacological blockade of V1b receptors reduces alcohol relapse in alcohol-dependent patients. SSR149415 is a selective V1b receptor antagonist that has potential for development as an alcohol dependency treatment. In this study, we investigated wheth...

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Publicat a:Alcohol Clin Exp Res
Autors principals: Zhou, Yan, Rubinstein, Marcelo, Low, Malcolm J., Kreek, Mary Jeanne
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5750120/
https://ncbi.nlm.nih.gov/pubmed/29105118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.13544
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