Neoadjuvant radiochemotherapy decreases the total amount of tumor infiltrating lymphocytes, but increases the number of CD8+/Granzyme B+ (GrzB) cytotoxic T-cells in rectal cancer

Although neoadjuvant radiochemotherapy (nRCTx) is an established oncological treatment in patients with advanced rectal cancer, little is known about its effects on the tumor microenvironment. Quantity and composition of tumor infiltrating lymphocytes (TILs) are known to influence patients' pro...

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Bibliografische gegevens
Gepubliceerd in:Oncoimmunology
Hoofdauteurs: Jarosch, Armin, Sommer, Ulrich, Bogner, Andreas, Reißfelder, Christoph, Weitz, Jürgen, Krause, Mechthild, Folprecht, Gunnar, Baretton, Gustavo B., Aust, Daniela E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2017
Onderwerpen:
Original Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749657/
https://ncbi.nlm.nih.gov/pubmed/29308324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1393133
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