Neoadjuvant radiochemotherapy decreases the total amount of tumor infiltrating lymphocytes, but increases the number of CD8+/Granzyme B+ (GrzB) cytotoxic T-cells in rectal cancer

Although neoadjuvant radiochemotherapy (nRCTx) is an established oncological treatment in patients with advanced rectal cancer, little is known about its effects on the tumor microenvironment. Quantity and composition of tumor infiltrating lymphocytes (TILs) are known to influence patients' pro...

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Vydáno v:Oncoimmunology
Hlavní autoři: Jarosch, Armin, Sommer, Ulrich, Bogner, Andreas, Reißfelder, Christoph, Weitz, Jürgen, Krause, Mechthild, Folprecht, Gunnar, Baretton, Gustavo B., Aust, Daniela E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2017
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Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749657/
https://ncbi.nlm.nih.gov/pubmed/29308324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1393133
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