Neoadjuvant radiochemotherapy decreases the total amount of tumor infiltrating lymphocytes, but increases the number of CD8+/Granzyme B+ (GrzB) cytotoxic T-cells in rectal cancer

Although neoadjuvant radiochemotherapy (nRCTx) is an established oncological treatment in patients with advanced rectal cancer, little is known about its effects on the tumor microenvironment. Quantity and composition of tumor infiltrating lymphocytes (TILs) are known to influence patients' pro...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Jarosch, Armin, Sommer, Ulrich, Bogner, Andreas, Reißfelder, Christoph, Weitz, Jürgen, Krause, Mechthild, Folprecht, Gunnar, Baretton, Gustavo B., Aust, Daniela E.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749657/
https://ncbi.nlm.nih.gov/pubmed/29308324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1393133
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