Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11–JAK/STAT3 pathway

Germline mutations in the gene encoding tumor suppressor kinase LKB1 lead to gastrointestinal tumorigenesis in Peutz-Jeghers syndrome (PJS) patients and mouse models; however, the cell types and signaling pathways underlying tumor formation are unknown. Here, we demonstrated that mesenchymal progeni...

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Vydáno v:J Clin Invest
Hlavní autoři: Ollila, Saara, Domènech-Moreno, Eva, Laajanen, Kaisa, Wong, Iris P.L., Tripathi, Sushil, Pentinmikko, Nalle, Gao, Yajing, Yan, Yan, Niemelä, Elina H., Wang, Timothy C., Viollet, Benoit, Leone, Gustavo, Katajisto, Pekka, Vaahtomeri, Kari, Mäkelä, Tomi P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749537/
https://ncbi.nlm.nih.gov/pubmed/29202476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI93597
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