Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest

Germ-line mutations of LKB1 (STK11) lead to Peutz–Jeghers syndrome characterized by gastrointestinal polyps and cancer of different organ systems. The mutations lead to loss or severe impairment of Lkb1 serine/threonine kinase activity. Therefore LKB1 has been implicated as a tumor suppressor gene,...

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Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Tiainen, Marianne, Ylikorkala, Antti, Mäkelä, Tomi P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 1999
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC17765/
https://ncbi.nlm.nih.gov/pubmed/10430928
Etiketler: Etiketle
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