Hedgehog signaling drives medulloblastoma growth via CDK6

Medulloblastoma, an aggressive cancer of the cerebellum, is among the most common pediatric brain tumors. Approximately one-third of medulloblastomas are associated with misactivation of the Hedgehog (Hh) pathway. GLI family zinc finger 2 (GLI2) coordinates the Hh transcriptional program; however, t...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Raleigh, David R., Choksi, Pervinder K., Krup, Alexis Leigh, Mayer, Wasima, Santos, Nicole, Reiter, Jeremy F.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2017
Matèries:
Concise Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749513/
https://ncbi.nlm.nih.gov/pubmed/29202464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92710
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