Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2α and Its Paralog CK2α′

Protein kinase CK2, a member of the eukaryotic protein kinase superfamily, is associated with cancer and other human pathologies and thus an attractive drug target. The indeno[1,2-b]indole scaffold is a novel lead structure to develop ATP-competitive CK2 inhibitors. Some indeno[1,2-b]indole-based CK...

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Veröffentlicht in:Pharmaceuticals (Basel)
Hauptverfasser: Hochscherf, Jennifer, Lindenblatt, Dirk, Witulski, Benedict, Birus, Robin, Aichele, Dagmar, Marminon, Christelle, Bouaziz, Zouhair, Le Borgne, Marc, Jose, Joachim, Niefind, Karsten
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748653/
https://ncbi.nlm.nih.gov/pubmed/29236079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph10040098
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