Diacritic Binding of an Indenoindole Inhibitor by CK2α Paralogs Explored by a Reliable Path to Atomic Resolution CK2α′ Structures

[Image: see text] CK2α and CK2α′ are the two isoforms of the catalytic subunit of human protein kinase CK2, an important target for cancer therapy. They have similar, albeit not identical functional and structural properties, and were occasionally reported to be inhibited with distinct efficacies by...

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Detalhes bibliográficos
Publicado no:ACS Omega
Main Authors: Lindenblatt, Dirk, Nickelsen, Anna, Applegate, Violetta M., Hochscherf, Jennifer, Witulski, Benedict, Bouaziz, Zouhair, Marminon, Christelle, Bretner, Maria, Le Borgne, Marc, Jose, Joachim, Niefind, Karsten
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6756786/
https://ncbi.nlm.nih.gov/pubmed/31559376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b03415
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