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PARP Inhibition by Flavonoids Induced Selective Cell Killing to BRCA2-Deficient Cells
High consumption of dietary flavonoids might contribute to a reduction of cancer risks. Quercetin and its glycosides have PARP inhibitory effects and can induce selective cytotoxicity in BRCA2-deficient cells by synthetic lethality. We hypothesized that common flavonoids in diet naringenin, hesperet...
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| 出版年: | Pharmaceuticals (Basel) |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
MDPI
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5748637/ https://ncbi.nlm.nih.gov/pubmed/29023372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph10040080 |
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