Hypersensitivity of BRCA2 deficient cells to rosemary extract explained by weak PARP inhibitory activity

Rosemary extract is used in food additives and traditional medicine and has been observed to contain anti-tumor activity. In this study, rosemary extract is hypothesized to induce synthetic lethality in BRCA2 deficient cells by PARP inhibition. Chinese hamster lung V79 cells and its mutant cell line...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Su, Cathy, Gius, Jeffrey P., Van Steenberg, Julia, Haskins, Alexis H., Heishima, Kazuki, Omata, Chisato, Iwayama, Masahiro, Murakami, Mami, Mori, Takashi, Maruo, Kohji, Kato, Takamitsu A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5711971/
https://ncbi.nlm.nih.gov/pubmed/29196727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16795-3
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