A Computational Workflow Translates a 58-Gene Signature to a Formalin-Fixed, Paraffin-Embedded Sample-Based Companion Diagnostic for Personalized Treatment of the BRAF-Mutation-Like Subtype of Colorectal Cancers

Colorectal cancer patients with the BRAF(p.V600E) mutation have poor prognosis in metastatic setting. Personalized treatment options and companion diagnostics are needed to better treat these patients. Previously, we developed a 58-gene signature to characterize the distinct gene expression pattern...

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Publicado en:High Throughput
Main Authors: In’t Veld, Sjors G. J. G., Duong, Kim N., Snel, Mireille, Witteveen, Anke, Beumer, Inès J., Delahaye, Leonie J. M. J., Wehkamp, Diederik, Bernards, René, Glas, Annuska M., Tian, Sun
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748595/
https://ncbi.nlm.nih.gov/pubmed/29479053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ht6040016
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