A small-molecule activator of kinesin-1 drives remodeling of the microtubule network

The microtubule motor kinesin-1 interacts via its cargo-binding domain with both microtubules and organelles, and hence plays an important role in controlling organelle transport and microtubule dynamics. In the absence of cargo, kinesin-1 is found in an autoinhibited conformation. The molecular bas...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Randall, Thomas S., Yip, Yan Y., Wallock-Richards, Daynea J., Pfisterer, Karin, Sanger, Anneri, Ficek, Weronika, Steiner, Roberto A., Beavil, Andrew J., Parsons, Maddy, Dodding, Mark P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748212/
https://ncbi.nlm.nih.gov/pubmed/29229862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1715115115
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